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Description
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris

They both contain common allergens, fragrances and oils

We detected higher oxidized states of Cys 170 of phosphofructokinase (PFK), Cys 247 of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Cys 379/80 of phosphoglycerate kinase (PGK) and Cys 49 and Cys 326 of pyruvate kinase M (PKM), which were all reported to interfere with either the primary or secondary function of these enzymes 32,33,34,35

Despite its toxicity potential, pipermethystine may not be the responsible for the hepatotoxicity reports in Germany in the 2000s, as stated by Lechtenberg et al