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This is a novel integrated neurohormonal strategy recently employed for obesity drug development

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Common sources of exosomes include: MSC-derived exosomes PRP-exosome hybrids Adipose exosomes Platelet-derived extracellular vesicles (P-EVs) The following chart shows the efficacy of various exosomes for pain reduction and cartilage regeneration: BMAC and MFAT BMAC (Bone Marrow Aspirate Concentrate) and MFAT (Micro-Fragmented Adipose Tissue) are orthobiologics rich in mesenchymal stem cells (MSCs), growth factors, and anti-inflammatory mediators