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GLP-1 receptor agonists such as exenatide, liraglutide, semaglutide, and tirzepatide provide glucose-dependent insulin stimulation, weight reduction, and cardiovascular benefits

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After overeating, Wnt/-catenin signal transduction in adipose tissue is inhibited, manifesting as increased expression of inhibitors of the canonical Wnt signalling pathway, such as SFRP2, FRZB/SFRP3, and DKK3, and increased phosphorylation and total GSK-3 levels

This upregulation of the GH receptor potentiated the proliferative effects of growth hormone, as evidenced by increased cell proliferation (MTT assay) and proliferating cell nuclear antigen (PCNA) expression