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2011 Sep;94(3):84753
In fact, oxidative stress can lead to the decrease of DNA-binding activities of activator protein-1 and CREB (cyclic AMP-response element-binding protein) which is associated with the reduction of BDNF (brain-derived neurotrophic factor) gene expression, as well as oxidative stress, and can result in impairment of NMDA channel function that is related to the decrease in BDNF gene expression
R.FernandesP
Future studies of the compound should use male mice to confirm that its effects are not sex-specific
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