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In rare cases, surgical intervention may be necessary to address plantar fasciitis that cannot be resolved with nonsurgical measures
It also upregulates growth factors, modulates inflammatory cytokines, activates FAK-paxillin signaling (which drives cell migration into injury sites), and supports collagen synthesis
In explaining its decision, the agency flagged concerns about complexities with regard to peptide-related impurities and active pharmaceutical ingredient (API) characterization, the potential for aggregation and a lack of human safety data
