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resolved tendon-bone defect Staresinic etal (2006) [48] Male Wistar rats Effect of BPC-157 on quadriceps muscle healing post-transection Improved quadriceps muscle macroscopic and microscopic structural, functional, and biomechanical indices Krivic etal (2008) [23] Male Wistar rats Effect of BPC-157 on Achilles tendon healing post-transection Decreased inflammatory infiltrates, increased vascular indices, and increased functional indices (BPC-157 with methylprednisolone) Novinscak etal (2008) [33] Male Wistar rats Effect of BPC-157 on muscle crush injury Improved macroscopic and microscopic muscle structures and restored functional indices Brcic etal (2009) [2] Male Wistar rats Angiogenic effect of BPC-157 in muscle and tendon transection Increases local vascularity and VEGF expression in muscle and tendon transection models Pevec etal (2010) [36] Male Wistar rats Effect of BPC-157 on a corticosteroid-impaired muscle healing model Improved structural and functional muscle healing despite concurrent corticosteroid treatment Cerovecki etal (2010) [4] Male Wistar rats Effect of BPC-157 on MCL healing at 90 days post-transection Reduced postinjury valgus instability and contracture, restored motor function indices, MCL biomechanical indices, macroscopic and microscopic structures Chang etal (2011) [6] Cultured tendon explants and fibroblasts from Sprague-Dawley rats Effect of BPC-157 on cultured Achilles tendon Increased ex vivo outgrowth of tendon explants, migration of tendon fibroblasts, and cell survival under stress Chang etal (2014) [5] Cultured Sprague- Dawley rat tendon fibroblast Effect of BPC-157 on tendon fibroblasts Increased growth hormone receptor expression and activity in cultured tendon fibroblasts Japjec etal (2021) [19] Male Wistar rats Effect of BPC-157 on quadriceps tendon healing post-transection Improved tendon macroscopic and microscopic structures, reduced inflammatory infiltrates, and resolved myotendinous defect Lee etal (2021) [25] Human knees (retrospective) Effect of BPC-157 on chronic knee pain 7 of 12 patients reported subjective improvement in symptoms for more than 6 months (intraarticular BPC-157 injection) Vasireddi et al

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