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Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs

doi: 10.1186/s13045-019-0720-y 145 HuMZhangYMaSLiJWangXLiangMet al

The importance of the proportion of cells carrying a healthy allele is emphasized by the observation that in two CALD patients the arrest of inflammation by autologous hematopoietic stem cell gene therapy could be achieved by long-term correction of only about 16% of CD34 + -derived cells, as determined by ABCD1-positivity of peripheral granulocytes, monocytes, T and B cells [5,6]