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Many excellent reviews on NQO1-targeted imaging have been published [130,140,141,142,143]

We have developed a novel, stable formulation of reduced glutathione for oral delivery (sold as ReadiSorb liposomal reduced glutathione by YES, LLC of Palo Alto, Calif.) and report that liposomal encapsulation markedly enhances the cellular bioavailability of reduced glutathione, meaning the novel, stable formulation is both storable for long periods and survives oral administration, and as a result, intracellular glutathione is enhanced and achieves results not achievable by non-intravenous administration of either plain glutathione (in any form) or non-liposomal reduced glutathione (which is normally largely oxidized in the gastrointestinal tract)

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At first, it appears as convex with an inrolled margin and then often becomes funnel-shaped along with wavy-margins