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(2021) meta-analysis suggests that through every illness stage, even before onset of psychosis, Glx levels in the basal ganglia are increased, though the group differences are reduced in patients with antipsychotic treatment, consistent with longitudinal studies (see below)

5-Amino-1MQ is not an acute-effect compound there is no same-day kick. Everything below is research-framed and drawn largely from animal-model observations

This reduced activity, combined with a potentially slower metabolism that can occur with persistent nutrient deficiencies, could indirectly contribute to weight gain over time

hence, a deficiency can occur