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Introduction Nicotine is the well-known chemical compound, that responsible for addiction in tobacco smoking, which conceder as the main cause of mortality worldwide, it is easily absorbed by lung, and has about 2 h as half-time in plasma before it is excreted through the kidneys,[] and hence, it has the ability to change levels of oxidative stress markers in lung and blood.[ , ] Malondialdehyde (MDA) is a main oxidative marker considered a very reactive chemical compound which produced through arachidonic acid metabolism at prostaglandins production.[] It can join with some important groups of molecules as ribonucleic acid, DNA, lipoproteins, and proteins and modification its vital function.[] Estimation of MDA levels in vital fluids and tissues use as a significant signal of lipid peroxidation at different body disorders, exposure to toxins and chemicals like heavy smoking.[ , ] Glutathione (GSH) is a chief cellular antioxidant commonly called the master antioxidant.[] It has vitally important role for the safety of lung and its ordinary function

dry inner bark 1 g, Matricaria chamomilla (Chamomile) flower extract dry concentrate 75 mg equiv

Social isolation, which reduces endogenous oxytocin signaling, is epidemiologically associated with accelerated biological aging and increased all-cause mortality to a degree comparable to smoking 15 cigarettes a day, a finding that may partly reflect disrupted oxytocin biology [20]

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