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Description
Causes and Risk Factors Common causes and risk factors for developing flat feet include: A foot abnormality present since birth Torn or stretched tendons Inflammation or damage to the posterior tibial tendon which runs from the lower leg down to the ankle, and to the middle of the arch of the foot Dislocated or broken bones in the legs or feet Health conditions (e.g., rheumatoid arthritis) Nerve damage, such as from peripheral neuropathy Other risk factors, such as obesity and partaking in frequent high-impact physical activity, like military training, may also lead to the development of flat feet

This article presents one of the initial studies to determine clinical factors that are predictive of long-term disability

The synergy between the two pathways is what makes the combination dosing more efficient per unit of compound

Zafra and Gimenez 2008
