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This suppressive effect of hemin is reversible by DMF, which induces CBS expression in an NRF2-dependent and independent manner

Given the increasing number of in vitro and animal studies that show the metabolic and behavioral benefits and safety of ITC, it is now important that clinical trials be expanded to facilitate their application in patients with disorders of the nervous system

Additionally, it has been proposed that compounds similar to MTCA may be associated with anxious behaviors, which are common in addictions (Piacente et al., 2002)
