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23 mM) was the component responsible of the local pain experienced after the SC administration of EPO-alfa [39]

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Firstly, it directly damages ocular tissues, provoking inflammation and immune cell infiltration ( 2 Oxidative stress in TAO 2.1 Basic concept of oxidative stress Oxidative stress occurs when there is an imbalance between ROS production and the antioxidant defense systems capacity to neutralize them ( Oxidative stress plays an important role in the pathomechanism of TAO

Biochim Biophys Acta (2013) 1830(5):314353