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MnSOD is elevated in primary tumors with lymph node metastases while comparing gastric cancer patients with and without metastasis, indicating that MnSOD and ROS are involved in metastasis (164)

Interestingly, in one study, the authors used metformin, which activates AMPK and autophagy, and it was studied in diabetic patients to improve insulin sensitivity and lipid metabolism

The formation of zinc-protoporphyrin is well document and arises during periods of iron limitation [55]

Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema
