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Nonetheless, further investigation is needed to elucidate the biological effect of this type of agent [186]

Mutations in mtDNA or the direct impact of proinflammatory mediators such cytokines, prostaglandins, ROS, and nitric oxide may contribute to mitochondrial dysfunction in chondrocytes in KOA (Kim J

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Makris G, Chouliaras G, Apostolakou F, Papageorgiou C, Chrousos GP, Papassotiriou I, Pervanidou P (2021) Increased serum concentrations of high mobility group box 1 (HMGB1) protein in children with autism spectrum disorder