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[DOI] [PMC free article] [PubMed] [Google Scholar] 293.Datta R., Kumar D., Sultana A., Hazra S., Bhattacharyya D., Chattopadhyay S

The ferroptosis inducing compounds rsl3 and ml162 are not direct inhibitors of gpx4 but of txnrd1

Glutathione (GSH): Glutathione provides major intracellular antioxidant activity, GSH is essential for neutralizing free radicals, regenerating vitamins C and E, supporting mitochondrial energy metabolism, and protecting DNA from oxidative stress

This approach successfully revealed interactions that conventional pull-downs could not detect, including stable ZAD dimerization and mutually exclusive binding of ENY2 with Sgf11 or CTCF fragments
