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Figure 1 Here, we focus on the natural molecules resveratrol, quercetin, fisetin, curcumin, and berberine, and elucidate their effect on SIRT1 activation and their potential to treat and/or prevent several human pathologies, mainly associated with metabolic disorders ( Figure 2 )

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This review summarizes current evidence regarding the role of ferroptosis in osteoporosis, with particular focus on its effects on osteoblasts, osteoclasts, and osteocytes, as well as the impact of aging, estrogen deficiency, diabetes, glucocorticoid exposure, and obesity on ferroptosis in osteogenic cells

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