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NNMT takes nicotinamide, a form of vitamin B3, and attaches a methyl group to it, using SAM (S-adenosylmethionine) as the methyl donor

With respect to pericytes, experimental studies using pericyte-deficient mice generated by crippling PDGFB- PDGFR- (EC-pericyte) signaling have demonstrated that the loss of pericyte has dramatic effect on EC morphology and function characterized by a venous-shifted molecular pattern of capillary EC, abnormal and irregular patterns of EC tight and adherens junctions and increased EC transcytosis culminating in diffuse and hotspot BBB leakage (661)

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Data availability Data supporting these findings are included within the article and its supplementary material or from the corresponding author upon request