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[16] Elevated levels following injection may persist for up to two weeks and should be considered when interpreting test results

The expression of the gene encoding heparanase is regulated epigenetically and by tumor suppressor p53, but can also be induced by early growth response stimulation of transcription factor-1, reactive oxygen species, and inflammatory cytokines (64)

Even though the data is extensive it is not enough to explain any relationship between these molecules and the independent MetS factors, or any mechanism by which these molecules could be involved in the pathophysiology