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If oral B12 replacement has been trialled in a person with metformin-associated B12 deficiency, I would suggest that a repeat measurement of B12 levels after 812 weeks is a good time to reassess whether absorption is adequate or whether a switch to intramuscular replacement is required

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The z13 receptor CNGB3 is highly expressed in endometrial glandular epithelial cells and peritoneal surfaces in specimens collected from endometriosis patients (Fig

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Biology, Mendelian randomisation, and discordance data all point in that direction, but we are not there yet with trial data

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Its better for some patients

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