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Two other models were evaluated, one in vitro (in PC-12 cells treated with glutamate) and another in vivo (in male mice treated with AlCl 3 )
The main collagen crosslinking enzymes include lysyl oxidase (LOX) and the lysyl oxidase-like isoforms (LOXL), whereas non-enzymatic crosslinking is mainly mediated by the formation of advanced glycation end products (AGEs)
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