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Using intracranial injections of a lentiviral short hairpin RNA (shRNA) construct to lower Gsto2 selectively in iSPNs of Trkb mutant mice prevented the dopaminergic dysfunction, improved energy metabolism, and other molecular rescues

Many patients report feeling more energized and focused within days
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Despite these protective mechanisms, elevated serum B12 levels (hypercobalaminaemia) can occur and may indicate underlying health conditions rather than simple overconsumption
