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After overnight incubation at 37 C, the medium was replaced with DMEM containing various CGA concentrations

Additionally, the activities of CS-exposed activated macrophages and neutrophils result in the release of IL-1 and TNF- into the local environment of the lungs

In the case of the essential amino acid sensor, GCN2, we predicted it would play a key role in detecting the immediate decrease in methionine and mediating the subsequent responses, but its absence failed to prevent either the acute transcriptional increase in hepatic Fgf21 and other ATF4 target genes (supplementary Fig