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As HIF-1 accumulates stably, the metabolic flow within macrophages rapidly shifts from mitochondrial oxidative phosphorylation (OXPHOS) to a high-throughput energy supply mode dominated by glycolysis (125)

Consequently, Mycoplasma consume nutrients within the cell culture media, outcompeting host cells for essential nutrients, such as amino acids, fatty acids, sugars, nucleic acid precursors, and choline, which can result in a wide range of cellular defects
143,144 The lipid antigen -GalCer is known to stimulate NKT cells

10.1111/j.1476-5381.1992.tb12789.x