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Description
It is characterized by abnormal metabolism of the three major nutrients and suppression of mitochondrial oxidative phosphorylation (OXPHOS), which contributes to the onset and development of DKD
They suffer specifically from insulin deficiency in the hepatic portal circulation as a result of the subcutaneous delivery of insulin (reviewed by Dunger (64))

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Oxidative stress determination is limited in daily clinical practice, primarily due to the difficulty in measuring the different aspects of oxidative stress, which entails several tests: oxidized glutathione, reduced glutathione, glutathione peroxidase, and glutathione reductase (GRd)
