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Description
Epub 2017 Jul 15

Deeply elucidating molecular anti-aging mechanisms, investigating interactions with other aging-related signaling pathways (such as mTOR, AMPK, etc.), improving the functional network, and providing theoretical support for more efficient anti-aging interventions

14 Noticeably, a triple mutant (tm, K100A/E101A/E103A) of NNMT was designed to retain a comparable activity as the wild type NNMT, but reduce the entropy to facilitate its crystallization

Nat Rev Drug Discov
