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In a study in diet-treated diabetic patients, even a single mixed meal of 450 Calories caused immediate and significant impairment in endothelial function, a key early step in the development of atherosclerosis

doi: 10.1016/j.bbr.2014.08.014

Regions of the brain that contain cell types expressing H 3 R include basal ganglia, cortex, hippocampus and strial area

The most common side effects are transient flushing and mild nausea, occurring in 1525% of users during the first 710 days
