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In recent years, investigators have found that the GLS1 isoform GAC is highly expressed in different types of cancers such as breast cancer, pancreatic cancer, and malignant leukemia [18]

Although the role of NO in regulating adipocyte differentiation is still unclear, a similar mechanism has been proposed to be responsible for the upregulation of adipocyte differentiation leading to the development of obesity

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Three specific gaps separate this preclinical evidence from a human recommendation, and it is worth naming each so the framing throughout this guide is not mistaken for false modesty