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FIGURE 8 Nine different substances were declared as PCT medicines in the samples and, in order of occurrence frequency, they were hCG (n = 16), clomiphene (n = 14), tamoxifen (n = 7), exemestane (n = 7), anastrozole (n = 7), cabergoline (n = 6), mesterolone (n = 4), and letrozole (n = 2)

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E 1 is then reduced to the more biologically active estradiol (E 2 ) by the action of 17-hydroxysteroid dehydrogenase (17-HSD) type 1 [27]