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Unauthorized drugs may also: lead to infections, allergic reactions, and other serious complications contain too much, too little, or none of the active ingredient contain unlisted, dangerous or unknown ingredients contain contaminants, such as solvents, heavy metals, particles (fibers, glass, plastic), or microbials (bacteria, fungi, endotoxins) be poorly or incorrectly labelled be improperly manufactured or stored interact with other medications or health products you may be taking.

The no-DAC version is commonly referred to as modified GRF 1-29 in research contexts

According to the National Academies of Sciences, Engineering, and Medicine (NAP), a safe highest level is called the tolerable upper intake level. Assessment of what amount is too much is based on animal and human studies, published evidence of adverse events, and professional agreement based on a committee of experts