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Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation

Unlike melatonin, which mainly regulates sleep-wake timing, DSIP seems to impact sleep depth and quality

Instead of replacing hormones, it works with your bodys own system