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However, a 2007 scientific review of the current literature discussed the limitations of the clinical trial, noting that the study had low statistical power, a high dropout rate and "insufficient baseline measurement to compare the effect of NAC", concluding that "a separate larger trial is needed to justify the benefit of long-term NAC therapy"

Research has shown that the expression levels of PPAR and PGC-1 were reduced in various experimental models of heart failure [25, 26]

[DOI] [PubMed] [Google Scholar] 4.Accili D, Arden KC

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