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Although the serum MMA concentration reflects an intracellular cobalamin deficiency, other causes of elevated MMA must be considered, such as renal failure, reduced plasma volume reduction, and abnormalities in hepatic methyl-malonyl CoA mutase activity [15,47]

The primary endpoint was not met

Therefore, the available literature on zonulin as a non-invasive marker for disease characterized by barrier dysfunction should be interpreted with extreme caution

Mechanisms underlying muscle healing enhancement include increased angiogenesis supporting tissue oxygenation and nutrient delivery, enhanced satellite cell activation for muscle regeneration, and reduced inflammatory damage during acute injury phases