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The MHRA (2022) recently issued guidance on the increased risk of vitamin B12 deficiency in people treated with metformin, highlighting increased risks with higher metformin doses, longer treatment duration and in patients with risk factors for B12 deficiency, including the following: Existing low B12 levels

The trial was, however, terminated early due to low enrolment 24 patients in total were enrolled, which made it impossible to draw meaningful conclusions from the data due to the small sample size (53)

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