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While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

The enzyme analyses were carried out using commercially available kits in accordance with the manufacturers instructions (BioVision, Milpitas, CA, USA)

The most common reason is hypoglycaemia (low blood sugar), particularly in patients taking Mounjaro alongside other glucose-lowering medications such as sulfonylureas or insulin

Environmental stress causes oxidative damage to plant mitochondria leading to inhibition of glycine decarboxylase