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The research project was approved by our institution (Universidad Complutense de Madrid) and by the "Real Federacin Hpica Espaola"

PRDX enzymes primarily regulate ROS generated during TCR signalling, rather than ROS produced during overt stress responses

1 Introduction Neurodegenerative diseases (NDDs) comprise a heterogeneous group of disorders characterized by the progressive loss of neurons or myelin in the brain and spinal cord, including Alzheimers disease (AD), Parkinsons disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntingtons disease (HD) (Wilson et al., 2023)

Similarly, Yubero-Serrano et al