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However, PGC-1 is a transcriptional coactivator that does not bind directly to DNA but regulates gene expression by interacting with other transcription factors

Additionally, myocardial fibrosis increases the stiffness of the myocytes, causing systolic or diastolic disorders [106]

Nature 578 , 600604 (2020)

Kolovrat et al., 2020) rapidly activating alternative bypassing pathways to adequately reestablish the blood flow (Vukojevic et al., 2018
