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Moreover, re-treatment with lycopene is recommended to prevent the symptoms from recurring

Quercetin can reduce the expression of inflammatory cytokines and BBB permeability marker genes ( Mmp9 , Vegf , Ang-2 , and Et-1 ), increase the expression of angiogenesis genes ( Sema4D and PlexinB1 ), reduce parasite-induced tight junction disruption, and inhibit the activation of the parasite-induced PI3K/AKT/extracellular signal-regulated kinase (ERK) signaling pathway, thus exerting a therapeutic effect on meningitis (Sun et al., 2024)

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