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Apart from mutations, other significant factors accounting for -synuclein fibrillation are changes in pH of the microenvironment (Puspita et al., 2017), phosphorylation (Shtilerman et al., 2002) as well as presence of other proteins in the vicinity (Uversky et al., 2002)

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Thus, copper is indispensable for cellular metabolism, particularly the mitochondrial respiratory chain [20, 23]