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Pathophysiology of Cryoglobulinemic Vasculitis Cryoglobulinemic vasculitis is considered a systemic small-to-medium vessel vasculitis.[22] In this disorder, damage to the vessels is thought to result from the deposition of immune complexes on the vessel wall, followed by subsequent activation of the complement cascade.[17] Only about 10 to 15% of persons with cryoglobulinemia develop cryoglobulinemic vasculitis.[22] Manifestations of Cryoglobulinemic Vasculitis Individuals with chronic HCV infection who develop cryoglobulinemic vasculitis most often have cutaneous manifestations, though any organ may be affected

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The level of MDA and NO was found to be significantly inhibited in both protective (GbE + PTZ and LC + PTZ) and therapeutic (PTZ + GbE and PTZ + LC) groups compared to PTZ-treated animals