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Signaling pathways regulating the immune function of cochlear supporting cells and their involvement in cochlear pathophysiology

Nielsen A

Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11 (Liu Y

doi: 10.3389/fphar.2018.01162 Received 30 May 2018 Accepted 24 September 2018 Published 16 October 2018 Volume 9 - 2018 Edited by Andres Trostchansky, Universidad de la Repblica, Uruguay Reviewed by Suowen Xu, University of Rochester, United States