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While the range of intracellular ascorbate concentrations in mammalian cells is 0.15 mM [8] and therefore may not be significant for superoxide scavenging, it approaches 1025 mM or more in chloroplasts [15], [16] and 10 mM in neurons [17] and could therefore cooperate with SOD to remove superoxide and decrease peroxinitrite formation

Microbiologyopen 8 , e00756

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