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While these diseases have distinct etiologies and pathologies, they all involve neuronal loss and sustained activation of the brains immune system, including microglia and astrocytes ( A key driver of neuronal injury is oxidative stress, which arises when the generation of reactive oxygen species (ROS) overwhelms the brains antioxidant defenses, one such defense being glutathione (GSH) (Tfilin et al., 2023)

Small tweaks to technique changing the site, spacing injections differently, or modest shifts in needle angle can reduce repeated soreness

For example, the command norm.cdf(1) will give us the area to the left of the z-score 1

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