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As per recent studies, the translation of the mRNAs of seleno-GPxs having low priority for selenium utilization (like GPx1) is not favored under low intracellular selenium status due to the interaction of a selenium responsive negative regulator such as eukaryotic initiation factor 4a3 (eIF4a3) with their 3-UTR (Fig

Strategies such as targeted delivery of antioxidants to healthy tissues or exploiting differences in the oxidative environments of cancerous versus normal cells are being explored to address this challenge [212, 213]

Improved Blood Sugar Control: Enhances insulin sensitivity and lowers blood glucose levels, making it promising for type 2 diabetes treatment

[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Crescenzi E., Leonardi A., Pacifico F