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Critically, this pathway operates independently of the GH receptor meaning AOD-9604 doesnt affect IGF-1 levels, hepatic glucose output, or insulin sensitivity

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12 , 13 Moderate physical activity and healthy diets promote a balanced microbiome (eg, a high Bacteroidetes to Firmicutes ratio) along with the production of neurotransmitters (eg, serotonin, dopamine), secondary bile acids, and short-chain fatty acids, including acetate, propionate, and butyrate (Figure 1)