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We estimated the mass of a placenta ( mp ) as 10% of the mass of the calf based on observations of killer whale placentas 53

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Resveratrol attenuates NF-B activation by blocking the phosphorylation and degradation of its inhibitory subunit, IB, thereby preventing nuclear translocation of the NF-B p65 subunit, which reduces the expression of inflammatory cytokines, including IL-1, IL-6, and TNF- ( In parallel, Resveratrol enhances the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, upregulating activating transcription factor 4 (ATF4) and ATF6, this suppresses endoplasmic reticulum (ER) stress markers, including CCAAT/enhancer binding protein homologous protein (CHOP), glucose-regulated protein 78 (GRP78), and X-box binding protein 1 (XBP1), while boosting the activity of antioxidant enzymes such as SOD, CAT, and GSH-Px, as well as controlling NAD phosphate (NADPH) oxidase-mediated ROS generation, reducing lipid peroxidation markers like MDA levels, and suppressing nitric oxide (NO) overproduction, thereby exerting anti-inflammatory and anti-oxidant effects ( 5.2 Reducing the expression of VEGF Cyclical angiogenesis is critical for maintaining follicular growth, ovulation, and subsequent corpus luteum development and regression