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The primary injury in FPI models involves contusion, shearing/stretching of cortical tissue, subdural hematoma and hemorrhage (Liu et al., 2010

L-GSH supplementation for 3-months resulted in a significant decrease in the levels of MDA in plasma ( Figure 4C ), PBMCs ( Figure 4D ), and RBCs ( Figure 4E )

The reaction formula can be summarized as follows: 2 GSH GSSG + 2H + 2e (under the action of GPX or ROS) However, to prevent GSSG accumulation from disrupting the intracellular sulfhydryl balance, cells need to rapidly convert it back to GSH through an efficient reduction system

Of particular interest is TREM2, an innate immune receptor expressed on microglia, for which mutations have been linked to an increased risk of AD [67]