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Recent studies also show that -sitosterol suppresses pro-survival signaling cascadesfor instance, an oxidized -sitosterol derivative significantly downregulated phosphorylated ERK1/2 and NF-B p65 levels, leading to increased ceramide accumulation and apoptosis in breast and liver cancer cells (97)
Non-canonical independent defense systems In addition to the canonical GPX4/GSH axis, cells possess other parallel, GPX4-independent anti-ferroptotic pathways that provide additional layers of protection
di Domenico, A
Respiratory Research , 14 , 112
