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Description
If liver disease or cancer causes elevated B12, specialists treat the primary condition

This difference may be explained by the results of in vitro binding studies, which showed that daratumumab can directly bind CD38 on RBCs, whereas isatuximab requires a cofactor (e.g., a mouse anti-CD38 antibody or a CD38 inhibitor), suggesting masking of the isatuximab epitope on RBCs in some patients [49, 50]

However, it may cause mild nasal discomfort in some people

Had site injection soreness that prevented me from sleeping on that side for 2 nights
