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[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Zhang JV et al
doi: 10.1016/j.atherosclerosis.2011.12.039
Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions
Importantly, treatment of DIO mice with our NNMT inhibitors did not impact food intake, but produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects
